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Cefotetan Disodium e Hipoprotrombinemia

Resultado da verificação da interação do medicamento Cefotetan Disodium com doença Hipoprotrombinemia quanto a segurança no uso em conjunto.

Resultado da verificação:

Cefotetan Disodium <> Hipoprotrombinemia

Relevância: 23.07.2019 Revisor: Shkutko P.M., M.D., in

Na verificação da interação, conforme informações das fontes confiáveis como Drugs.com, Rxlist.com, Webmd.com, Medscape.com, foram identificadas as contra-indicações ou efeitos colaterais que podem prejudicar a saúde ou aumentar efeito negativo ao consumir o medicamento com esta doença concomitante.

Consumidor:

Hypoprothrombinemia, com ou sem sangramento, tem sido relatado raramente com várias cefalosporinas, especialmente aqueles que contêm um N-methylthiotetrazole (NMTT) cadeia lateral (cefamandole, cefmetazole, cefoperazone, cefotetan). O sulfhydryl grupo desta cadeia lateral é suspeito de interferir com a síntese hepática de protrombina. Fatores de risco incluem idade avançada, fraqueza, deficiência de vitamina K, desnutrição, má absorção, e renal grave ou hepatobiliar de imparidade. O tratamento com cefalosporinas contendo o NMTT cadeia lateral deve ser administrado com cautela em pacientes com qualquer um desses fatores de risco significativo e/ou sangramento ativo ou de uma diátese hemorrágica. Administração profilática de vitamina K pode ser indicado em alguns pacientes, especialmente quando intestinal esterilização e procedimentos cirúrgicos são realizados.

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